Product Detail

99% High Quality Original Powder Carbamazepine CAS 298-46-4 with Safe Delivery

Basic Information

Description
Carbamazepine (CBZ), sold under the tradename Tegretol among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain.It is not effective for absence seizures or myoclonic seizures. It is used in schizophrenia along with other medications and as a second line agent in bipolar disorder.Carbamazepine appears to work as well as phenytoin and valproate. Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain;Carbamazepine is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy.;Carbamazepine is also used to treat bipolar disorder.

Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It is used off-label as a second-line treatment for bipolar disorder and in combination with an antipsychotic in some cases of schizophrenia when treatment with a conventional antipsychotic alone has failed. It is not effective for absence seizures or myoclonic seizures. In the United States, the FDA-approved medical uses are epilepsy (including partial seizures, generalized tonic-clonic seizures and mixed seizures), trigeminal neuralgia, and manic and mixed episodes of bipolar I disorder.

Function

The mechanism of action of carbamazepine and its derivatives is relatively well understood.[medical citation needed] Carbamazepine is a use-dependant blocker of voltage-gated sodium channels. It is ionised within intracellular fluid, and is then able to bind to activated voltage-gated sodium channels, preventing repetitive and sustained firing of an action potential.This leaves the affected cells less excitable until the drug dissociates. Carbamazepine is also a GABA receptor agonist, as it has also been shown to potentiate GABA receptors made up of alpha1, beta2, and gamma2 subunits.[26] This mechanism may contribute to its efficacy in neuropathic pain and bipolar disorder. Laboratory research has further demonstrated that carbamazepine is a serotonin releasing agent and possibly even a serotonin reuptake inhibitor.

COA

Items		Standard
Appearance		White to Off-white Powder
Identification	IR	Corresponding to the spectrum of reference standard
	UPLC	Retention time of the sample conforms to that of the reference standard
X-ray Diffraction		Corresponding to Reference Spectrum
Acidity		≤1.0mL/g (0.010mol/LNaOH)
Alkalinity		≤1.0mlL/g (0.010mo/L HCl)
Loss on Drying		≤0.5%
Residue on lgnition		≤0.1%
Chlorides		≤0.014%
UPLC Related Compounds	10,11-Dihydrocarbamazepine	≤0.2%
	lminostillbene	≤0.2%
	Any Other lmpurity	≤0.2%
	Total Impurities	≤0.5%
UPLC Assay(Dried Basis)		98.0-102.0%
HS-GC Residual Solvents	Methanol	≤3000ppm
	Ethanol	≤5000ppm
	Chlorobenzene	≤360ppm