Biocar Pharmaceutical Co.,Ltd. 
Appearacnce: Brick Red Crystalline PowderCAS: 2030-63-9Storage: Cool Dry PlaceDeliver Time: 7-10 DaysShelf Life: 2 YearsBrand: BIOCAR
Product Detail
99% High Quality Original Powder Clofazimine CAS 2030-63-9 with Safe Delivery
Basic Information
Product name | Clofazimine |
Synonyms | N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino) phenazin-2-amine |
CAS No. | 2030-63-9 |
EINECS | 217-980-2 |
Molecular formula | C27H22Cl2N4 |
Molecular weight | 473.39 |
Appearance | Brick red crystalline powder |
Melting point | 212-213°C |
Boiling point | 566.9°Cat760mmHg |
Assay | 99% |
Packing | 100g;500g;1Kg; |
Application | Pharcaceutical Intermediates |
Description
Clofazimine, sold under the brand name Lamprene, is a medication used together with rifampicin and dapsone to treat leprosy. It is specifically used for multibacillary (MB) leprosy and erythema nodosum leprosum. Evidence is insufficient to support its use in other conditions though a retrospective study found clofazimine to be 95% effective in the treatment of Mycobacterium avium complex (MAC) when administered with a Macrolide and Ethambutol, as well as the drugs Amikacin and Clarithromycin. However, in the United States, Clofazimine is considered and orphan drug, is unavailable in pharmacies, and its use in the treatment of MAC is overseen by the Food and Drug Administration. It is taken by mouth.
Common side effects include abdominal pain, diarrhea, itchiness, dry skin, and change in color of the skin. May also cause swelling of the lining of the gastrointestinal tract, increased blood sugar, and sensitivity to the sun. It is unclear if use during pregnancy is safe. Clofazimine is a phenazine dye and believed to work by interfering with DNA.
Clofazimine was discovered in the 1950s at Trinity College, Dublin, and approved for medical use in the United States in 1986. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. In the United States it is not available commercially but can be obtained from the US Department of Health and Human Services.
Function
The primary use of clofazimine is for the treatment of leprosy. Other uses have not been proven to be safe or effective.
It has been studied in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in people with HIV/AIDS and Mycobacterium avium paratuberculosis. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum (ENL). . The drug is given as an alternative to people who can not tolerate the effects of dapsone for leprosy.
Specification
Item | Standard | |
Structural data confirmation | 1. H-NMR: The data of structure are identical with reference standard | |
2. HPLC-MS: Ensure the molecular weight of main peak and fragment peak are identical with reference standard | ||
3. IR:The data of IR are identical with that of reference standard | ||
Purity(HPLC) | ≥99.0% | |
Related impurities | Specific single impurity | |
Non-specific single impurity | ||
Total Impurities | ||
Crystal form | Meets EP/USP/BP standards | |
Loss on drying | ≤1.0% | |
Water | ≤1.0% | |
Inorganic salt | ≤0.1% | |
Heavy metals | ≤10 ppm | |
Assay | 99.0%~101.0%(According to EP/USP/BP standards) | |
Microbiological Analysis | ||
Total plate count | ≤1000cfu/g | |
Yeast and Moulds | ≤100cfu/g | |
E. Coli. | Absent | |
Salmonella | Absent | |
S.aureus | Absent | |
Our Company
Wuhan Biocar Pharmaceutical Co., Ltd. is a hightech innovative enterprise specializing in the R & D, production and sales of API and pharmaceutical intermediates (excluding drugs). Our company is based on the optical valley biological city, with the help of Wuhan University Scientific Research Laboratory, making full use of the park policy advantages, focusing on the research and development of biological medicine. Our company always adheres to the business philosophy of "market demand oriented; technology research and development as the core competitiveness; e-commerce as the platform", more accurate, better, faster and more reliable to provide biomedical products for pharmaceutical units, university scientific research institutions, hospital outpatient service, reagent units, distributors in the world.
