Biocar Pharmaceutical Co.,Ltd. 
Appearance: White Crystal PowderCAS: 1094-61-7Storage: Cool Dry PlaceSelf Life: 2 YearsDeliver Time: 7-10 DaysBrand: BIOCAR
Product Detail
99% High Quality Original Powder NMN CAS 1094-61-7 with Safe Delivery
Basic Information
| Model NO. | TGY072019040908 |
| Product Name | Beta-Nicotinamide Mononucleotide |
| Appearance | White Crystal Powder |
| Test Methods | HPLC |
| Shelf Life | 2 Years |
| Shipping Methods | DHL, FedEx, TNT and EMS |
| MOQ | 10g |
| CAS No. | 1094-61-7 |
| Mf | C11H15N2O8P |
| Trademark | TGY |
| Transport Package | Foil Bag, Box, Drum |
| Specification | 98%min |
| Origin | China |
| HS Code | 2804400000 |
Why is NAD+ so Important?
NAD+ enables cells to generate cellular energy from the food that we eat. It is also an important substrate for a variety of NAD+-consuming enzymes (including PARPs and sirtuins). Even though scientists have known about this molecule for more than 100 years, there are more studies being published on NAD+ than ever before. This resurgence of scientific interest is partly sparked by research showing NAD+ can decrease over time and under metabolic stress. Some scientists even think that declining NAD+ levels may play a major role in the aging process.
In 1906, nicotinamide adenine dinucleotide (NAD+) was discovered as an important coenzyme in human body, and the relationship between NAD+ level and aging has been continuously clarified in the past century [1,2]. In 2007, NAD+ direct precursor nicotinamide RIbose (NR) was officially launched as the "elixir of life" [3]. In 2013, another direct precursor of NAD+, nicotinamide mono-nucleotide (NMN), was also discovered by the "star producer" geneticist David A. Sinclair
Why boost NAD+?
NAD has been shown to decline with age and metabolic stress. It has also been demonstrated to help support many aspects of healthy aging:
- Increases cellular metabolism and energy production
- Maintains healthy mitochondria
- Promotes cellular repair
* Reverse Aging
*Acticating longevity protein of Sirtuin 1~7
* Increase NAD+ leave
* Activate the immune system
*Protection of Cardiovascular and Cerebrovascular
*Protect brain neurons
Description
Nicotinamide mononucleotides play an important role in the production of human cell energy, which is involved in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion).
Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. It is to be used for research only.
Fuction
1. Nicotinamide mononucleotide in human cells play an important role in energy generation, it is involved in intracellular NAD (nicotinamide adenine dinucleotide, cell energy conversion important coenzyme) synthesis, used in anti-aging, fall blood sugar and other health care products.
2. Nicotinamide Mononucleotide is a water-soluble vitamin, The product is white crystalline powder, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin.
3. Nicotinamide Mononucleotide is easy to absorb oral, and can be widely distributed in the body, the excess metabolites or prototype quickly expel from urine. Nicotinamide is part of coenzyme I and coenzyme II plays the role of hydrogen delivery in biological oxidation respiratory chain, can promote biological oxidation processes and tissue metabolism, maintain normal tissue (especially the skin, digestive tract and nervous system) integrity has an important role.
Application
The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.
NMNAT1 is the most widely expressed of three orthologous genes with nicotinamide-nucleotide adenylyltransferase (NMNAT) activity. Genetically engineered mice lacking NMNAT1 die during early embryogenesis, indicating a critical role of this gene in organismal viability.[citation needed] In contrast, mice lacking NMNAT2, which is expressed predominantly in neural tissues, complete development but die shortly after birth. However, NMNAT1 is dispensable for cell viability, as homozygous deletion of this gene occurs in glioblastoma tumors and cell lines. NMNAT enzymatic activity is probably essential at the cellular level, as complete ablation of NMNAT activity in model organisms leads to cellular inviability.
COA
| Items | Specification | Results |
| Appearance | White to pale yellow crystalline powder | White crystalline powder |
| Appearance of solution (5% w/v in water) | Colorless to pale yellow and clear | Colorless and clear |
| Water | ≤6.0% | 0.5% |
| Arsenic | ≤1 PPM | < 1 PPM |
| Lead | ≤1 PPM | < 1 PPM |
| Mercury | ≤1 PPM | < 1 PPM |
| Heavy Metal | ≤10 PPM | < 10 PPM |
| Assay(Dry basis) | 97.0% - 100.0% | 98.1% |
| Conclusion: The product conforms with the enterprise standard. | ||
Wuhan Biocar Pharmaceutical Co., Ltd. is a high-tech innovative enterprise specializing in the R & D, production and sales of API and pharmaceutical intermediates (excluding drugs). Our company is based on the optical valley biological city, with the help of Wuhan University Scientific Research Laboratory, making full use of the park policy advantages, focusing on the research and development of biological medicine. Our company always adheres to the business philosophy of "market demand oriented; technology research and development as the core competitiveness; e-commerce as the platform", more accurate, better, faster and more reliable to provide biomedical products for pharmaceutical units, university scientific research institutions, hospital outpatient service, reagent units, distributors in the world.
