Biocar Pharmaceutical Co.,Ltd. 
Appearance: White PowderCAS: 2627-69-2Deliver Time: 7-10 DaysSelf Life: 2 YearsStorage: Cool Dry PlaceBrand: BIOCAR
Product Detail
99% High Quality Wholesales Original Powder Aicar CAS 2627-69-2 with Safe Delivery
Basic Information
Product Name
Aicar
Aicar Alias
Acadesine
Aicar CAS
2627-69-2
Aicar Assay
99%min
Aicar Usage
Pharmaceutical intermediates. For the treatment of cardiovascular diseases
Appearanced
White powder
Density
2.06 g/cm3
Boiling Point
726.3ºC at 760 mmHg
Melting point
214-215 °C
Flash point
393.1ºC
Refractive index
1.821
Storage Condition
-20ºC
Vapor pressure
3.83E-22mmHg at 25°C
Pruty
99%min
Molecular Weight
258.231
Exact Mass
258.096
Molecular Formula
C9H14N4O5
HS.Code
2934999090
Brand
Biocar
EINECS NO.
220-097-5
Description
(1). It is an intermediate contained in the generation of inosine monophosphate.It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production.
(2). AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).
(3). AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion.
(4). With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion.Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.
Function
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
Wuhan Biocar Pharmaceutical Co., Ltd. is a high-tech innovative enterprise specializing in the R & D, production and sales of API and pharmaceutical intermediates (excluding drugs). Our company is based on the optical valley biological city, with the help of Wuhan University Scientific Research Laboratory, making full use of the park policy advantages, focusing on the research and development of biological medicine. Our company always adheres to the business philosophy of "market demand oriented; technology research and development as the core competitiveness; e-commerce as the platform", more accurate, better, faster and more reliable to provide biomedical products for pharmaceutical units, university scientific research institutions, hospital outpatient service, reagent units, distributors in the world.
