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Biocar Pharmaceutical Co.,Ltd. 2021 Registered
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Wholesales 99% High Quality Original Powder Gliclazide CAS21187-98-4 with Safe Delivery Inquiries(0) Tags:Gliclazide CAS21187-98-4 Price: US $1.201-1000 Quantity: piece Total price:US $0.00 (Excluding shipping cost) Add to Inquiry Cart Add to Wish List (0 Adds) Ship From: Hongkong Support Payment Terms: T/T,L/C Biocar Pharmaceutical Co.,Ltd. 2021 Registered

Hubei, China. This supplier has been open since 2004

Business Type: SOHO/Individual Main Products: Samrs, Steroids Seller Homepage
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  • +86 15970428662
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  • Niky@biolang.cn
  • +86 15970428662
  • +86 15970428662
  • +86 15970428662
  • Biolake 858 High-tech Avenue, Wuhan, Hubei, China
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Item Specifications
  • Appearance:White Powder
  • CAS:21187-98-4
  • Storage:Cool Dry Place
  • Deliver Time:7-10 Days
  • Self Life:2 Years
  • Brand:BIOCAR
Product Description

Product Detail

Wholesales 99% High Quality Original Powder Gliclazide CAS21187-98-4 with Safe Delivery

Basic Information

Name:Gliclazide
Purity: 99%
Cas no.:21187-98-4
Appearance: White Powder
Supply Ability : 2Mt/Per Month
Storage: Store in a well-closed container away from moisture

Description   

Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It has been classified differently according to its drug properties in which based on its chemical structure, gliclazide is considered a first-generation sulfonylurea due to the structural presence of a sulfonamide group able to release a proton and the presence of one aromatic group. On the other hand, based on the pharmacological efficacy, gliclazide is considered a second-generation sulfonylurea which presents a higher potency and a shorter half-life. Gliclazide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%).

Function   

1.Gliclazide is used for control of hyperglycemia in gliclazide-responsive diabetes mellitus of stable, mild, non-ketosis prone, type 2 diabetes. It is used when diabetes cannot be controlled by proper dietary management and exercise or when insulin therapy is not appropriate. National Kidney Foundation (2012 Update) claims that Gliclazide does not require dosage uptitration even in end stage kidney disease.
2.Fall blood sugar medicine, used in the treatment of non insulin dependent diabetes
3.It is mainly used for adult onset diet alone invalid, and no diabetes ketosis tendency of light duty.
4.Also improve diabetics fundus diseases and metabolic disorder of blood vessel function.

Usage:   
1. For adults with type 2 diabetes, diabetes associated with obesity or vascular lesions.
2. Hypoglycemic agents. It can be used for the treatment of non-insulin dependent diabetes mellitus.
3. Hypoglycemic agents, non-insulin dependent diabetes mellitus.


COA

ItemsStandard of qualityResults of analysis
CharacteristicsA white or almost white powderA white powder
Solubility Practically insoluble in water;freely soluble in dichloromethane;sparingly soluble in acetone;slightly soluble in alcohol.Meets the requirements
IdentificationThe infrared absorption spectrum is concordant with the reference spectrumMeets the requirements
Impurity B≤2ppm0.1ppm
Related substancesImpurity F ≤0.15%Non-detected
Other individual impurity≤0.10%0.03&
Total unknown impurity≤0.20%0.05%
Loss on drying≤0.25%0.2%
Sulphated ash ≤0.1%0.03%
Residual SolventsEthyl acetate NMT 2500ppm175ppm
Toluene NMT 890 ppmNon-detected
Ethanol NMT 5000ppmNon-detected
THF NMT 720ppmNon-detected
Assay99.0%-101.0%99.7%

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